Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL2781429 | 0.96 | FFAR4 (0.56) | FFAR4FFAR1GPR84TBXAS1TBXA2R | |
| Succinic Acid SCHEMBL2785641 | 0.93 | FFAR4 (0.51) | FFAR4FFAR1GPR84TBXAS1FAAH | |
| Succinic Acid SCHEMBL2782794 | 0.90 | FFAR4 (0.36) | FFAR4FFAR1GPR84TBXAS1KDM4E | |
| SCHEMBL9995078 | 0.90 | USP2 (0.40) | FFAR4FFAR1GPR84KDM4EDUSP3 | |
| Adipic Acid SCHEMBL2782511 | 0.89 | FFAR4 (0.58) | FFAR4FFAR1GPR84TBXAS1MEN1 | |
| Dodecanoate SCHEMBL9615275 | 0.88 | FFAR4 (0.60) | FFAR4FFAR1GPR84MEN1KMT2A | |
| Adipic Acid SCHEMBL2780883 | 0.87 | FFAR4 (0.44) | FFAR4FFAR1GPR84TBXAS1KDM4E | |
| Acetic Acid SCHEMBL9720486 | 0.87 | GPR84 (0.46) | FFAR4FFAR1GPR84FAAHKDM4E | |
| SCHEMBL622450 | 0.85 | USP2 (0.43) | FFAR4FFAR1GPR84KDM4EDUSP3 | |
| SCHEMBL1122053 | 0.83 | USP2 (0.46) | FFAR4FFAR1GPR84KDM4EDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | claimed |
| EP-2202267-A1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-06-30 | — | — | EP | claimed |
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | disclosed |
| EP-2202267-A1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-06-30 | — | — | EP | disclosed |
| US-7166654-B2 | Ester compound, plasticizer for biodegradable aliphatic polyester resin, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-01-23 | — | — | US | disclosed |
| US-20050228092-A1 | Ester compound, plasticizer for bioegradable aliphatic polyester resin, and biodegradable resin composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2005-10-13 | — | — | US | disclosed |