Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 10/20 | 0.51 |
| ▸ | NOS1 | P29475 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675198 | 0.90 | NOS3 (0.62) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL2675388 | 0.90 | NOS3 (0.47) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL2675520 | 0.88 | NOS3 (0.56) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL2675017 | 0.86 | NOS3 (0.61) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL2675512 | 0.86 | NOS3 (0.49) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL2677052 | 0.85 | NOS3 (0.62) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL499211 | 0.84 | NOS3 (0.52) | NOS3NOS1MAPTNOS2MEN1 | |
| SCHEMBL2674397 | 0.84 | TP53 (0.48) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL2676597 | 0.84 | NOS3 (0.63) | NOS3NOS1TP53LMNAKCNH2 | |
| SCHEMBL4112042 | 0.84 | NOS3 (0.61) | NOS3NOS1TP53LMNAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |