Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 20/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27825686 | 0.91 | CFTR (0.50) | CFTR | |
| SCHEMBL27804848 | 0.87 | CFTR (0.52) | CFTR | |
| SCHEMBL4122517 | 0.87 | CFTR (0.47) | CFTR | |
| SCHEMBL27804842 | 0.85 | CFTR (0.51) | CFTR | |
| SCHEMBL12027069 | 0.85 | CFTR (0.58) | CFTR | |
| SCHEMBL27825454 | 0.84 | CFTR (0.46) | CFTR | |
| SCHEMBL27977473 | 0.83 | CFTR (0.48) | CFTR | |
| SCHEMBL27825584 | 0.82 | CFTR (0.48) | CFTR | |
| SCHEMBL4121715 | 0.82 | CFTR (0.47) | CFTR | |
| SCHEMBL27804843 | 0.82 | CFTR (0.44) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103951614-A | Pyridyl derivatives as CFTR modulators | VERTEX PHARMA | 2014-07-30 | — | — | CN | disclosed |
| CN-101981011-A | Pyridyl derivatives as CFTR modulators | VERTEX PHARMA | 2011-02-23 | — | — | CN | disclosed |