Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27826853 | 0.88 | ZAP70 (0.35) | ACVR1JAK3EGFRLCKBTK | |
| SCHEMBL27806015 | 0.87 | MAP3K12 (0.37) | ACVR1JAK3EGFRLCKBTK | |
| SCHEMBL27806329 | 0.86 | BTK (0.36) | TGFBR1JAK3EGFRLCKBTK | |
| SCHEMBL27805887 | 0.85 | NAMPT (0.34) | JAK3EGFRLCKBTKSTK17A | |
| SCHEMBL28787067 | 0.84 | JAK3 (0.35) | JAK3EGFRLCKBTKIGF1R | |
| SCHEMBL27806366 | 0.83 | IGF1R (0.35) | ACVR1JAK3EGFRLCKBTK | |
| SCHEMBL27826747 | 0.82 | JAK2 (0.33) | JAK3EGFRLCKBTKIGF1R | |
| SCHEMBL27806061 | 0.82 | JAK2 (0.37) | JAK3JAK2PTK2 | |
| SCHEMBL27805849 | 0.82 | P2RY14 (0.36) | JAK3SYKJAK2PTK2 | |
| SCHEMBL28790529 | 0.82 | STK17A (0.38) | ACVR1JAK3EGFRLCKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101990539-A | Compounds and compositions as kinase inhibitors | IRM LLC | 2011-03-23 | — | — | CN | disclosed |