Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807351 | 1.00 | MAPK1 (0.35) | MAPK1TSHRMAPTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27807316 | 0.82 | CHEK1 (0.39) | TSHR | |
| SCHEMBL27902769 | 0.81 | MAPK1 (0.35) | MAPK1MAPTLMNASMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL27821411 | 0.81 | RPS6KA3 (0.37) | TSHR | |
| Hydrochloric Acid SCHEMBL27821429 | 0.81 | RPS6KA3 (0.37) | TSHR | |
| SCHEMBL27827936 | 0.81 | MAPK1 (0.37) | MAPK1 | |
| Hydrochloric Acid SCHEMBL27807322 | 0.80 | MAPK1 (0.36) | MAPK1 | |
| SCHEMBL3665162 | 0.80 | MAPK1 (0.35) | MAPK1MAPTLMNASMN1; SMN2CYP2D6 | |
| SCHEMBL11961245 | 0.76 | AKT1 (0.44) | TSHRLMNA | |
| SCHEMBL3730962 | 0.76 | CCR1 (0.35) | MAPK1TSHRSMN1; SMN2CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101965347-A | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2011-02-02 | — | — | CN | disclosed |