Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 8/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | FES | P07332 | 2/20 | 0.33 |
| ▸ | ROS1 | P08922 | 2/20 | 0.33 |
| ▸ | FER | P16591 | 2/20 | 0.33 |
| ▸ | FLT4 | P35916 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.33 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150696 | 0.88 | TGFBR1 (0.38) | TGFBR1TGFBR2CDK8PDK1MAP4K4 | |
| SCHEMBL4165700 | 0.88 | TGFBR1 (0.39) | TGFBR1TGFBR2CDK8PDK1MAP4K4 | |
| SCHEMBL27828792 | 0.88 | TGFBR1 (0.36) | TGFBR1TGFBR2CDK8PDK1MAP4K4 | |
| SCHEMBL27808283 | 0.88 | TGFBR1 (0.39) | TGFBR1TGFBR2CDK8MAP4K4CHEK2 | |
| SCHEMBL3722712 | 0.86 | TGFBR1 (0.39) | TGFBR1TGFBR2CDK8PDK1CYP3A4 | |
| SCHEMBL4158616 | 0.86 | TGFBR1 (0.42) | TGFBR1TGFBR2CDK8CLK2CYP3A4 | |
| SCHEMBL28787418 | 0.86 | TGFBR1 (0.40) | TGFBR1TGFBR2CDK8MAP4K4CHEK2 | |
| SCHEMBL3672347 | 0.83 | CDK8 (0.47) | TGFBR1TGFBR2CDK8CYP3A4CYP2C8 | |
| SCHEMBL4301753 | 0.82 | TGFBR1 (0.38) | TGFBR1TGFBR2CDK8PDK1MAP4K4 | |
| SCHEMBL27808346 | 0.81 | TGFBR1 (0.37) | TGFBR1TGFBR2PDK1IRAK4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | disclosed |