Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 16/20 | 0.71 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.42 |
| ▸ | ITGAV | P06756 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308479 | 0.91 | TPH1 (0.83) | TPH1 | |
| SCHEMBL308480 | 0.91 | TPH1 (0.83) | TPH1 | |
| SCHEMBL870470 | 0.89 | TPH1 (0.82) | TPH1 | |
| SCHEMBL870471 | 0.89 | TPH1 (0.82) | TPH1 | |
| SCHEMBL308642 | 0.83 | TPH1 (1.00) | TPH1 | |
| SCHEMBL308641 | 0.83 | TPH1 (1.00) | TPH1 | |
| SCHEMBL871411 | 0.80 | TPH1 (0.74) | TPH1 | |
| SCHEMBL871412 | 0.80 | TPH1 (0.74) | TPH1 | |
| SCHEMBL308166 | 0.79 | TPH1 (1.00) | TPH1 | |
| SCHEMBL308167 | 0.79 | TPH1 (1.00) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083454-A | Methods for diagnosing, preventing and treating bone mass disorders | UNIV COLUMBIA | 2011-06-01 | — | — | CN | disclosed |
| CN-101969952-A | Compositions comprising tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS INC | 2011-02-09 | — | — | CN | disclosed |
| CN-101815534-A | methods and compositions for treating pulmonary hypertension and related diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-08-25 | — | — | CN | disclosed |
| CN-101801385-A | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein | LEXICON PHARMACEUTICALS INC | 2010-08-11 | — | — | CN | disclosed |
| CN-101784269-A | methods of treating serotonin-mediated diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-07-21 | — | — | CN | disclosed |