Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL27809453 | 0.88 | CA12 (0.47) | CA12CA1CA2CA9EGFR | |
| Lysine SCHEMBL27787583 | 0.88 | EGFR (0.46) | EGFRNOX4RGS12ALDH1A1LCK | |
| Lysine SCHEMBL27787483 | 0.87 | CA1 (0.41) | CA12CA1CA2CA9EGFR | |
| SCHEMBL27749184 | 0.85 | EGFR (0.60) | CA12CA1CA2CA9EGFR | |
| Lysine SCHEMBL27809465 | 0.81 | EGFR (0.55) | CA12CA1CA2CA9EGFR | |
| Lysine SCHEMBL27787481 | 0.76 | CA1 (0.41) | CA12CA1CA2CA9EGFR | |
| Lysine SCHEMBL27787482 | 0.76 | EGFR (0.43) | CA12CA1CA2CA9EGFR | |
| SCHEMBL3112215 | 0.73 | ACLY (0.44) | MAPTTDP1GSRHPGDHSD17B10 | |
| SCHEMBL7809216 | 0.73 | EGFR (0.81) | EGFRNOX4RGS12ALDH1A1LCK | |
| SCHEMBL15367533 | 0.71 | CA12 (0.60) | CA12CA1CA2CA9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101792399-A | Aminosalicylic acid derivative lysine complex salt, preparation method and application thereof | UNIV NANJING MEDICAL | 2010-08-04 | — | — | CN | disclosed |