Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.74 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.74 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.64 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | PRKACA | P17612 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | PRKACG | P22612 | 1/20 | 0.59 |
| ▸ | PRKACB | P22694 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
| ▸ | PRKCG | P05129 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12650367 | 1.00 | ROCK2 (0.74) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL1492958 | 1.00 | ROCK2 (0.74) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL12650393 | 0.90 | ROCK2 (0.61) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL1492784 | 0.90 | ROCK2 (0.61) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL1492754 | 0.89 | PSEN1 (0.65) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL1492640 | 0.87 | PSEN1 (0.72) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL7980383 | 0.87 | PSEN1 (0.72) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL2183564 | 0.85 | PSEN1 (0.86) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| SCHEMBL3102020 | 0.85 | ROCK1 (1.00) | ROCK2ROCK1PRKG1CYP2C9PRKACA | |
| SCHEMBL1492759 | 0.85 | PSEN1 (0.58) | ROCK2ROCK1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083794-A | Urea compounds as gamma secretase modulators | AMGEN INC | 2011-06-01 | — | — | CN | claimed |