Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.49 |
| ▸ | WNT3A | P56704 | 3/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492774 | 0.88 | WNT3A (0.54) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492842 | 0.86 | WNT3A (0.54) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492808 | 0.83 | CNR1 (0.59) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492900 | 0.83 | WNT3A (0.48) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492669 | 0.82 | PSEN1 (0.49) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492752 | 0.81 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492836 | 0.79 | MAPK1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492843 | 0.79 | NPC1 (0.64) | ROCK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492943 | 0.79 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492960 | 0.78 | CNR1 (0.66) | ROCK2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083794-A | Urea compounds as gamma secretase modulators | AMGEN INC | 2011-06-01 | — | — | CN | claimed |
| CN-102083794-A | Urea compounds as gamma secretase modulators | AMGEN INC | 2011-06-01 | — | — | CN | disclosed |