Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30169622 | 0.89 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL3976082 | 0.89 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| Formic Acid Methyl Ester SCHEMBL28862470 | 0.85 | DRD2 (0.48) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL30919606 | 0.85 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL8414747 | 0.85 | DRD2 (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL31518368 | 0.83 | DRD2 (0.54) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL5149459 | 0.83 | DRD2 (0.54) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL29427010 | 0.81 | KDM1A (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL957833 | 0.81 | KDM1A (0.55) | DRD2DRD1DRD4DRD5DRD3 | |
| Bicarbonate SCHEMBL1719108 | 0.80 | HDAC4 (0.54) | DRD2DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083794-A | Urea compounds as gamma secretase modulators | AMGEN INC | 2011-06-01 | — | — | CN | disclosed |