Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.50 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.50 |
| ▸ | CCND1 | P24385 | 4/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CCND3 | P30281 | 4/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513050 | 0.84 | PDPK1 (0.80) | PDPK1HSP90AB1FGFR1CDK4CCNA2 | |
| Tert-Butyl Formate SCHEMBL27819524 | 0.82 | PDPK1 (0.44) | PDPK1HSP90AB1FGFR1CDK4CCNA2 | |
| Tert-Butyl Formate SCHEMBL27949495 | 0.82 | PDPK1 (0.44) | PDPK1HSP90AB1FGFR1FGFR2FGFR3 | |
| Tert-Butyl Formate SCHEMBL27819730 | 0.81 | PDPK1 (0.43) | PDPK1HSP90AB1FGFR1CDK4CCND1 | |
| Tert-Butyl Formate SCHEMBL27819466 | 0.79 | PDPK1 (0.41) | PDPK1HSP90AB1FGFR1CDK4CCNA2 | |
| Tert-Butyl Formate SCHEMBL27819460 | 0.79 | PDPK1 (0.41) | PDPK1HSP90AB1FGFR1CDK4CCND1 | |
| Tert-Butyl Formate SCHEMBL27839185 | 0.77 | HSP90AB1 (0.40) | PDPK1HSP90AB1FGFR1CDK4CCNA2 | |
| Tert-Butyl Formate SCHEMBL27819733 | 0.76 | MAPK1 (0.39) | PDPK1HSP90AB1FGFR1CDK4CCND1 | |
| Tert-Butyl Formate SCHEMBL27839182 | 0.75 | HSP90AB1 (0.40) | PDPK1HSP90AB1FGFR1CDK4CCNA2 | |
| SCHEMBL5378056 | 0.72 | DCLK1 (0.65) | PDPK1HSP90AB1FGFR1CDK2FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102089302-A | Nitrogenated bicyclic heterocyclic compound | ASAHI KASEI PHARMA CORP | 2011-06-08 | — | — | CN | disclosed |