Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27839186 | 0.80 | FLT3 (0.43) | MAPK1ALDH1A1HPGDGSK3B | |
| Tert-Butyl Formate SCHEMBL27819524 | 0.80 | PDPK1 (0.44) | MAPK1PDPK1HSP90AB1ESR1FGFR1 | |
| Tert-Butyl Formate SCHEMBL27949495 | 0.80 | PDPK1 (0.44) | PDPK1HSP90AB1ESR1FGFR1FGFR2 | |
| Tert-Butyl Formate SCHEMBL27819460 | 0.79 | PDPK1 (0.41) | MAPK1PDPK1HSP90AB1ESR1FGFR1 | |
| Tert-Butyl Formate SCHEMBL27819730 | 0.79 | PDPK1 (0.43) | PDPK1HSP90AB1ESR1FGFR1FGFR2 | |
| Tert-Butyl Formate SCHEMBL27819466 | 0.77 | PDPK1 (0.41) | PDPK1HSP90AB1ESR1FGFR1FGFR2 | |
| Tert-Butyl Formate SCHEMBL27811446 | 0.76 | PDPK1 (0.57) | MAPK1PDPK1HSP90AB1ESR1FGFR1 | |
| Tert-Butyl Formate SCHEMBL27839185 | 0.75 | HSP90AB1 (0.40) | MAPK1PDPK1HSP90AB1ESR1FGFR1 | |
| SCHEMBL27819731 | 0.75 | GABRA1 (0.43) | MAPK1 | |
| Tert-Butyl Formate SCHEMBL27839182 | 0.73 | HSP90AB1 (0.40) | MAPK1PDPK1HSP90AB1ESR1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102171191-A | Indazole derivative | ASAHI KASEI PHARMA CORP | 2011-08-31 | — | — | CN | claimed |
| CN-102171191-A | Indazole derivative | ASAHI KASEI PHARMA CORP | 2011-08-31 | — | — | CN | disclosed |