Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 9/20 | 0.38 |
| ▸ | CDK4 | P11802 | 8/20 | 0.38 |
| ▸ | CCND1 | P24385 | 8/20 | 0.38 |
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31524129 | 0.78 | NPC1 (0.51) | IRAK4CDK1CDK4CCND1CDK2 | |
| SCHEMBL3776834 | 0.76 | NSD2 (0.49) | IRAK4CDK1CDK4CCND1CDK2 | |
| SCHEMBL27818542 | 0.76 | IRAK4 (0.45) | IRAK4MAPK8MAPK9CDK1CDK4 | |
| SCHEMBL27735445 | 0.75 | IRAK4 (0.44) | IRAK4MAPK8MAPK9CDK1CDK4 | |
| SCHEMBL1936981 | 0.75 | IRAK4 (0.46) | IRAK4MCHR1MAPK8MAPK9CDK1 | |
| SCHEMBL1936977 | 0.75 | IRAK4 (0.46) | IRAK4MCHR1MAPK8MAPK9CDK1 | |
| SCHEMBL16671765 | 0.72 | PIK3CD (0.49) | IRAK4CDK1CDK4CCND1CDK2 | |
| SCHEMBL27796538 | 0.71 | ALDH1A1 (0.43) | MAPT | |
| SCHEMBL13015069 | 0.70 | CDK2 (0.47) | IRAK4MAPK8CDK1CDK4CCND1 | |
| Hydrochloric Acid SCHEMBL3770686 | 0.69 | CDK2 (0.46) | IRAK4MAPK8CDK1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102159547-A | Heterocyclic carboxamide compounds | ASTELLAS PHARMA INC | 2011-08-17 | — | — | CN | disclosed |