Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.62 |
| ▸ | CNR2 | P34972 | 3/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760339 | 0.88 | CNR2 (0.70) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL27923057 | 0.87 | CNR2 (0.64) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL27821228 | 0.87 | CNR2 (0.64) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL27800056 | 0.87 | CNR2 (0.80) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL27941757 | 0.82 | CNR1 (0.58) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL516738 | 0.81 | CNR2 (0.67) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL27465301 | 0.81 | SLC2A1 (0.55) | CNR1CNR2ACHEKDM4EPOLB | |
| SCHEMBL7818113 | 0.80 | CNR1 (0.56) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL8808522 | 0.80 | KDM4E (0.82) | CNR1CNR2ACHEKDM4EGUCY1B2 | |
| SCHEMBL8415791 | 0.79 | CNR1 (0.59) | CNR1CNR2ACHEKDM4EGUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101965337-B | Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 | ACRAF | 2013-11-06 | — | — | CN | disclosed |
| CN-101965337-A | Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 | ACRAF | 2011-02-02 | — | — | CN | disclosed |
| CN-101945855-A | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 | ACRAF | 2011-01-12 | — | — | CN | disclosed |