Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29723157 | 1.00 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL13212480 | 1.00 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL14165062 | 1.00 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL15786231 | 1.00 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL19673799 | 0.93 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL14839488 | 0.93 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL14839643 | 0.93 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL13232717 | 0.89 | PDE4D (0.60) | PDE4APDE4BPDE4CPDE4DABCB11 | |
| SCHEMBL13212454 | 0.89 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28759831 | 0.89 | PDE4D (0.65) | PDE4APDE4BPDE4CPDE4DABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056176-B2 | 1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-16 | — | — | US | disclosed |
| US-20140378423-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-12-25 | — | — | US | disclosed |
| US-8859778-B2 | 1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-10-14 | — | — | US | disclosed |
| EP-2760838-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2014-08-06 | — | — | EP | disclosed |
| US-20140179647-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-06-26 | — | — | US | disclosed |
| US-8648204-B2 | 1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-02-11 | — | — | US | disclosed |
| US-20130289010-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2013-10-31 | — | — | US | disclosed |
| US-8440834-B2 | 1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-05-14 | — | — | US | disclosed |
| WO-2013045280-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-04 | — | — | WO | disclosed |
| US-20130012487-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-01-10 | — | — | US | disclosed |
| EP-2393782-B1 | BENZOIC ACID (1-PHENYL-2-PYRIDIN-4-YL) ETHYL ESTERS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2012-09-12 | — | — | EP | disclosed |
| EP-2393782-A1 | BENZOIC ACID (1-PHENYL-2-PYRIDIN-4-YL) ETHYL ESTERS AS PHOSPHODIESTERASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089107-A1 | BENZOIC ACID (1-PHENYL-2-PYRIDIN-4-YL) ETHYL ESTERS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-08-12 | — | — | WO | disclosed |
| US-20100204256-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-08-12 | — | — | US | disclosed |
| EP-2216327-A1 | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204256-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
| US-20130289010-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
| US-20130012487-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
| US-20140378423-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
| US-20140179647-A1 | 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.