Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421684 | 0.83 | NQO2 (0.50) | NQO2MAPTKDM4ETP53HTT | |
| SCHEMBL6693971 | 0.83 | HTT (0.53) | MAPTKDM4ETP53HTTGAA | |
| SCHEMBL27529724 | 0.81 | CYP3A4 (0.54) | KDM4EGAACYP3A4PDGFRBFGFR1 | |
| SCHEMBL11551208 | 0.80 | CDC25B (0.58) | MAPTKDM4EHSD17B10BACE1LMNA | |
| SCHEMBL7768542 | 0.80 | NQO2 (0.46) | NQO2MAPTKDM4ETP53HTT | |
| SCHEMBL8941764 | 0.79 | MAPT (0.57) | MAPTKDM4EGAACYP3A4NPSR1 | |
| SCHEMBL29559115 | 0.79 | MAPT (0.57) | MAPTKDM4EGAACYP3A4NPSR1 | |
| SCHEMBL3267487 | 0.79 | ERN1 (0.47) | MAPTKDM4ETP53HTTCYP3A4 | |
| SCHEMBL27822167 | 0.79 | CYP3A4 (0.44) | MAPTKDM4ETP53HTTGAA | |
| SCHEMBL911036 | 0.78 | NQO2 (0.61) | NQO2MAPTKDM4ETP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102216273-A | Naphthylacetic acids used as crth2 antagonists or partial agonists | HOFFMANN LA ROCHE (CH) | 2011-10-12 | — | — | CN | disclosed |