Quinolin-4-Amine

Quinolin-4-Amine

SCHEMBL278276

Nc1ccnc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 3/20 1.00
LOXL2 Q9Y4K0 1/20 0.57
NR4A2 P43354 4/20 0.53
SOS2 Q07890 1/20 0.53
MAPT P10636 3/20 0.52
MEN1 O00255 1/20 0.52
LMNA P02545 1/20 0.52
HSP90AA1 P07900 1/20 0.52
HSP90AB1 P08238 1/20 0.52
HTT P42858 1/20 0.52
BLM P54132 1/20 0.52
KMT2A Q03164 1/20 0.52
HIF1A Q16665 1/20 0.52
PI4KA P42356 1/20 0.50
PI4K2B Q8TCG2 1/20 0.50
PI4K2A Q9BTU6 1/20 0.50
PI4KB Q9UBF8 1/20 0.50
ADRA1A P35348 3/20 0.48
HTR1A P08908 2/20 0.48
ADRA1D P25100 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinolin-4-Amine SCHEMBL29493365 1.00 NCF1 (1.00) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL5792741 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL29429801 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL28583906 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL6221275 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL4384971 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL14672386 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL30414452 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL20986747 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT
Quinolin-4-Amine SCHEMBL3997934 0.98 NCF1 (0.95) NCF1LOXL2NR4A2SOS2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4944 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118772738-B Self-adhesive coating for amorphous silicon steel sheet and preparation method thereof Changzhou Jiuye Material Technology Co.,Ltd. (CN) 2026-05-26 CN claimed
WO-2026102264-A2 HYDROXYCHLOROQUINE AS A PRETREATMENT TO ENHANCE AAV DELIVERY OF BROADLY NEUTRALIZING MONOCLONAL ANTIBODIES UNIVERSITY OF MIAMI (US) 2026-05-15 WO claimed
US-20250332118-A1 NOVEL ORAL CARE FORMULATIONS FOR TREATMENT OF XEROSTOMIA LIVIONEX INC (US) 2025-10-30 US claimed
CN-120136781-A ROR 1-targeted inhibitor and synthesis method and application thereof 北京大学 2025-06-13 CN claimed
CN-120058675-A Preparation and purification method and application of quinoline derivative with biological activity 河南科技大学 2025-05-30 CN claimed
EP-4251617-B1 (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS CHIESI FARM SPA (IT) 2025-03-12 EP claimed
CN-119584967-A Compositions and methods for treating hepatic porphyria with glycine transport inhibitors 迪斯克医药公司 2025-03-07 CN claimed
CN-119556538-A Alkaline stripping liquid for silicon-based surface composite film and stripping method thereof 湖北兴福电子材料股份有限公司 2025-03-04 CN claimed
CN-118979315-B Ultraviolet-resistant moisture-absorbing fiber and preparation method thereof 广东创时尚智能股份有限公司 2025-02-28 CN claimed
CN-119432383-A High-selectivity etching solution for radio frequency chip material 湖北兴福电子材料股份有限公司 2025-02-14 CN claimed
WO-1992001451-A1 METHOD FOR KILLING HIV-INFECTED CELLS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-02-06 WO claimed
US-5019574-A 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1991-05-28 US claimed
EP-0422097-A1 METHOD OF INHIBITING THE ACTIVITY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN VIVO. DAVIS MICHAEL H (US) 1991-04-17 EP claimed
US-5006535-A Substituted heterocylic 4-aminoquinoline derivatives as gastric acid secretion inhibitors SMITH KLINE & FRENCH LABORATORIES LTD. (GB) 1991-04-09 US claimed
WO-1990000055-A1 METHOD OF INHIBITING THE ACTIVITY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN VIVO DAVIS MICHAEL H (US) 1990-01-11 WO claimed
EP-0305968-A2 Compositions against protozoal diseases YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED (IL) 1989-03-08 EP claimed
EP-0152379-A2 Process for preparing pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY AG (CH) 1985-08-21 EP claimed
EP-0035856-B1 PHARMACEUTICAL AND DIETARY COMPOSITIONS EFAMOL LIMITED (GB) 1984-07-04 EP claimed
EP-0037175-A1 Pharmaceutical compositions EFAMOL LIMITED (GB) 1981-10-07 EP claimed
EP-0035856-A2 Pharmaceutical and dietary compositions EFAMOL LIMITED (GB) 1981-09-16 EP claimed