Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CD38 | P28907 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484302 | 0.88 | JAK3 (0.49) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2507819 | 0.83 | PTK2 (0.55) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL27847524 | 0.82 | CD38 (0.40) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2476348 | 0.81 | JAK3 (0.52) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2479562 | 0.81 | RPS6KB1 (0.55) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2482471 | 0.81 | RPS6KB1 (0.60) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL27847536 | 0.81 | JAK3 (0.52) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL12456033 | 0.80 | RPS6KB1 (0.54) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2480282 | 0.79 | JAK3 (0.67) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL12206941 | 0.79 | JAK3 (0.55) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102227409-A | Pyridine-3-carboxyamide derivative | KOWA CO | 2011-10-26 | — | — | CN | disclosed |