Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958106 | 0.92 | BCL2 (0.44) | FAAHALDH1A1BCL2SMN1; SMN2KDM4E | |
| SCHEMBL1957122 | 0.88 | BCL2 (0.43) | FAAHBCL2 | |
| SCHEMBL27831767 | 0.88 | KMT2A (0.47) | CYP2C9CYP2C19KMT2AALDH1A1MEN1 | |
| SCHEMBL27850404 | 0.86 | BCL2 (0.51) | CYP2C9CYP2C19CYP1A2CYP3A4BCL2 | |
| SCHEMBL27850269 | 0.85 | KMT2A (0.48) | CYP2C9CYP2C19KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1959132 | 0.80 | KMT2A (0.44) | KMT2AFAAHALDH1A1MEN1MAPT | |
| SCHEMBL1957648 | 0.80 | BCL2 (0.46) | BCL2TSHRKDM4E | |
| SCHEMBL1957509 | 0.79 | BCL2 (0.56) | BCL2 | |
| SCHEMBL28791299 | 0.78 | BCL2 (0.49) | BCL2 | |
| SCHEMBL1958252 | 0.75 | BCL2 (0.44) | KMT2AALDH1A1LMNAMMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |