Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Putrescine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA3 | P07451 | 3/20 | 0.47 |
| ▸ | CA4 | P22748 | 3/20 | 0.47 |
| ▸ | CA6 | P23280 | 3/20 | 0.47 |
| ▸ | CA5A | P35218 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.47 |
| ▸ | F13A1 | P00488 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL27839522 | 0.93 | TP53 (0.57) | TP53DNM1TSHRMEN1KMT2A | |
| Diethylamine SCHEMBL1492444 | 0.91 | DNM1 (0.67) | TP53DNM1TSHRNFKB1MEN1 | |
| Octadecylamine SCHEMBL27864463 | 0.88 | DNM1 (0.72) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Decylamine SCHEMBL27847057 | 0.88 | DNM1 (0.72) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Dodecylamine SCHEMBL27883896 | 0.88 | DNM1 (0.72) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Tetradecylamine SCHEMBL27864218 | 0.88 | DNM1 (0.72) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Diethylamine SCHEMBL1492440 | 0.88 | DNM1 (0.72) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Diethylamine SCHEMBL8751114 | 0.88 | DNM1 (0.72) | DNM1TSHRMEN1KMT2AALDH1A1 | |
| Butylamine SCHEMBL181352 | 0.87 | DNM1 (0.53) | TP53DNM1TSHRMEN1KMT2A | |
| Diethylamine SCHEMBL4738312 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102321237-B | Polylol for foamed plastic and polyisocyanurate foamed plastic adopting same | NANJING HONGBAOLI CO LTD | 2012-11-07 | — | — | CN | claimed |
| CN-102321237-A | Polylol for foamed plastic and polyisocyanurate foamed plastic adopting same | NANJING HONGBAOLI CO LTD | 2012-01-18 | — | — | CN | claimed |
| CN-102321237-B | Polylol for foamed plastic and polyisocyanurate foamed plastic adopting same | NANJING HONGBAOLI CO LTD | 2012-11-07 | — | — | CN | disclosed |
| CN-102762533-A | Switchable hydrophilicity solvents and methods of use thereof | UNIV KINGSTON | 2012-10-31 | — | — | CN | disclosed |
| CN-101395139-B | Sigma receptor compounds | ESTEVE LABOR DR | 2012-07-18 | — | — | CN | disclosed |
| CN-102321237-A | Polylol for foamed plastic and polyisocyanurate foamed plastic adopting same | NANJING HONGBAOLI CO LTD | 2012-01-18 | — | — | CN | disclosed |