Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.69 |
| ▸ | ACHE | P22303 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18274501 | 0.87 | ALDH1A1 (0.66) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL11007040 | 0.87 | ALDH1A1 (0.70) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL2778767 | 0.83 | ALDH1A1 (0.61) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL1019672 | 0.82 | ALDH1A1 (1.00) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL11159935 | 0.80 | ALDH1A1 (0.60) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL2899597 | 0.80 | ALDH1A1 (0.60) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL11154769 | 0.80 | ALDH1A1 (0.68) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL9162336 | 0.80 | ALDH1A1 (0.83) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL2784285 | 0.79 | ALDH1A1 (0.71) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL18274473 | 0.78 | ALDH1A1 (0.61) | ALDH1A1ACHESMN1; SMN2L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795256-B2 | Thieno-pyridinone derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2010-09-14 | — | — | US | disclosed |
| US-20070078131-A1 | Thieno-pyridinone derivatives as kinase inhibitors | CELLTECH R&D LIMITED (GB) | 2007-04-05 | — | — | US | disclosed |
| EP-1680429-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005042540-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078131-A1 | Thieno-pyridinone derivatives as kinase inhibitors | MAP3K6, MAP4K2, MAP3K15 | ALDH1A1 2586/4885ACHE 3989/4885SMN1; SMN2 3314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.