Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27914665 | 0.83 | SCN9A (0.43) | — | |
| SCHEMBL3318397 | 0.81 | FLT3 (0.42) | FLT3MERTKGAS6 | |
| SCHEMBL1126385 | 0.76 | NAMPT (0.46) | FLT3MERTKGAS6 | |
| SCHEMBL27851370 | 0.76 | KMT2A (0.41) | — | |
| SCHEMBL27833215 | 0.74 | — | — | |
| SCHEMBL3318399 | 0.74 | FLT3 (0.42) | FLT3MERTKGAS6 | |
| SCHEMBL28791680 | 0.73 | CYP3A4 (0.36) | AOC3 | |
| SCHEMBL27833137 | 0.73 | FLT3 (0.39) | FLT3MERTKGAS6AOC3 | |
| SCHEMBL23106917 | 0.72 | FLT3 (0.43) | FLT3MERTKGAS6 | |
| SCHEMBL27603372 | 0.72 | CYP3A4 (0.35) | AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102036963-B | Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors | NOVARTIS AG | 2013-08-21 | — | — | CN | disclosed |
| CN-102036963-A | Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors | NOVARTIS AG | 2011-04-27 | — | — | CN | disclosed |