Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 8/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.37 |
| ▸ | PPARD | Q03181 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27733852 | 0.93 | PSEN1 (0.39) | PHGDHPPARGPPARAPPARDPSEN1 | |
| SCHEMBL27733711 | 0.89 | PPARG (0.41) | PHGDHPPARGPPARAPPARDMEN1 | |
| SCHEMBL27833814 | 0.87 | PPARG (0.37) | PHGDHPPARGPPARAPPARDMEN1 | |
| SCHEMBL27813772 | 0.86 | PPARG (0.36) | PHGDHPPARGPPARAPPARDMEN1 | |
| SCHEMBL27733726 | 0.83 | PPARG (0.42) | PHGDHPPARGPPARAPPARDMEN1 | |
| SCHEMBL27733841 | 0.82 | F7 (0.36) | PHGDHPPARGPPARAPPARD | |
| SCHEMBL27733696 | 0.82 | PTGS1 (0.40) | PPARGPPARAPPARDMEN1KMT2A | |
| SCHEMBL28775109 | 0.81 | RECQL (0.39) | PHGDHPPARGPPARAPPARDMEN1 | |
| SCHEMBL28775103 | 0.81 | MEN1 (0.41) | PHGDHPPARGPPARAPPARDMEN1 | |
| SCHEMBL27713457 | 0.81 | PSEN1 (0.46) | PHGDHMEN1KMT2APSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102112441-B | Use of indole derivatives as NURR-1 activators for the treatment of parkinson's disease | FOURNIER LAB S A | 2013-07-10 | — | — | CN | disclosed |
| CN-102112441-A | Use of indole derivatives as NURR-1 activators for the treatment of parkinson's disease | FOURNIER LAB S A | 2011-06-29 | — | — | CN | disclosed |