Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.35 |
| ▸ | CHUK | O15111 | 5/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619275 | 0.86 | GABRA1 (0.37) | IKBKBCHUK | |
| SCHEMBL621276 | 0.78 | IKBKB (0.40) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL621275 | 0.78 | IKBKB (0.38) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL619495 | 0.77 | IKBKB (0.40) | IKBKBCHUKBTKCSF1RAURKA | |
| SCHEMBL10211418 | 0.75 | IKBKB (0.38) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL621659 | 0.73 | IKBKB (0.48) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL621660 | 0.73 | IKBKB (0.59) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL620273 | 0.73 | IKBKB (0.39) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL620274 | 0.73 | IKBKB (0.43) | IKBKBCHUKBTKCSF1RSLC6A4 | |
| SCHEMBL621661 | 0.73 | IKBKB (0.48) | IKBKBCHUKBTKCSF1RSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139322-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | Smithkline Beecham Corporation (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118724-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |