Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061664 | 0.86 | KMT2A (0.52) | MAPTALDH1A1TP53KMT2AL3MBTL1 | |
| SCHEMBL27651859 | 0.84 | CNR2 (0.55) | MAPTTP53KMT2AMEN1RXFP1 | |
| SCHEMBL27854511 | 0.81 | MAPK1 (0.46) | SMN1; SMN2RAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL11080007 | 0.76 | FEN1 (0.51) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL27854533 | 0.73 | PTGDR2 (0.41) | ALDH1A1KMT2AMEN1KDM4EPTGDR2 | |
| SCHEMBL27836564 | 0.73 | ALDH1A1 (0.41) | MAPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL27651848 | 0.72 | ALDH1A1 (0.48) | MAPTSMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL7837453 | 0.72 | CNR2 (0.67) | MAPTKMT2AMEN1RXFP1PTGDR2 | |
| SCHEMBL1061683 | 0.71 | ALDH1A1 (0.42) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4851227 | 0.70 | MEN1 (0.62) | MAPTALDH1A1KMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| CN-102015705-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2011-04-13 | — | — | CN | disclosed |