Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22579036 | 0.78 | TLR8 (0.54) | TLR8RAB9AKMT2ACYP1A2 | |
| SCHEMBL28691857 | 0.78 | KDM4E (0.37) | MKNK1TLR8HCRTR1HCRTR2KMT2A | |
| SCHEMBL7044155 | 0.78 | TLR8 (0.51) | TLR8RAB9AKMT2ACYP1A2HTR3A | |
| SCHEMBL1271431 | 0.77 | CYP1A2 (0.36) | TLR8CYP11B2RAB9AKMT2ACYP1A2 | |
| SCHEMBL3433191 | 0.77 | TLR8 (0.55) | TLR8RAB9A | |
| Phosphine SCHEMBL27716021 | 0.77 | TLR8 (0.52) | TLR8RAB9AKMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL27905861 | 0.76 | TLR8 (0.50) | TLR8RAB9AKMT2ACYP1A2HTR3A | |
| SCHEMBL716117 | 0.76 | TSHR (0.50) | TLR8HCRTR1HCRTR2CYP1A2HTR3A | |
| Hydrochloric Acid SCHEMBL27476977 | 0.75 | TSHR (0.49) | TLR8HCRTR1HCRTR2CYP1A2HTR3A | |
| SCHEMBL28700302 | 0.74 | KDM4E (0.37) | MKNK1TLR8HCRTR1HCRTR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102026985-A | Quinazoline derivatives as RAF kinase modulators and methods and uses thereof | AMBIT BIOSCIENCES CORPORATON | 2011-04-20 | — | — | CN | disclosed |