Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787178 | 0.84 | EPHX2 (0.55) | EPHX2MAPT | |
| SCHEMBL2784411 | 0.76 | EPHX2 (0.56) | EPHX2MAPK14MAPTTDP1MEN1 | |
| SCHEMBL2783672 | 0.75 | TP53 (0.48) | EPHX2MAPTMEN1KMT2A | |
| SCHEMBL24713130 | 0.74 | EPHX2 (0.58) | EPHX2MAPK14MAPTMEN1KMT2A | |
| SCHEMBL2784887 | 0.72 | HIF1A (0.39) | MAPTTDP1KMT2ARXFP1 | |
| SCHEMBL18727404 | 0.72 | MAPT (0.52) | MAPTTDP1MEN1KMT2A | |
| SCHEMBL2787195 | 0.71 | TP53 (0.63) | EPHX2MAPTKMT2A | |
| SCHEMBL2440155 | 0.71 | SMN1; SMN2 (0.52) | MAPTNPSR1 | |
| SCHEMBL2785316 | 0.70 | TP53 (0.52) | EPHX2MAPT | |
| SCHEMBL23447710 | 0.70 | MAPT (0.55) | MAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |