Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345837 | 0.91 | TSHR (0.55) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL28293056 | 0.89 | TSHR (0.53) | TSHRTHRBALDH1A1POLBAPEX1 | |
| Diethylamine SCHEMBL27862080 | 0.87 | TSHR (0.49) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL3898618 | 0.85 | TSHR (0.58) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL29035611 | 0.84 | TSHR (0.61) | TSHRTHRBALDH1A1POLBAPEX1 | |
| Diethylamine SCHEMBL27889742 | 0.83 | TSHR (0.51) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL27609944 | 0.80 | THRB (0.50) | TSHRTHRBALDH1A1POLBAPEX1 | |
| Diethylamine SCHEMBL499703 | 0.79 | TSHR (0.79) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL17727833 | 0.79 | TSHR (0.56) | TSHRTHRBALDH1A1POLBAPEX1 | |
| SCHEMBL28169127 | 0.78 | TSHR (0.43) | TSHRTHRBALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296982-B | Transparent inorganic-oxide dispersion, resin composition containing inorganic oxide particles, composition for encapsulating luminescent element, luminescent element, hard coat, optical functional film and optical device, preparation method of resin composition containing inorganic oxide particle | SUMITOMO OSAKA CEMENT CO LTD | 2012-09-19 | — | — | CN | disclosed |
| CN-102369225-A | Curable composition and cured product thereof | SHOWA DENKO KK | 2012-03-07 | — | — | CN | disclosed |