Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 5/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861665 | 0.82 | FDPS (0.59) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9671853 | 0.81 | SMN1; SMN2 (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL28245984 | 0.81 | FDPS (0.57) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL8504424 | 0.81 | FDPS (0.57) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL25260235 | 0.79 | FDPS (0.56) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL30969130 | 0.79 | FDPS (0.56) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL25260237 | 0.79 | FDPS (0.56) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7382527 | 0.78 | FDPS (0.54) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| Acetic Acid SCHEMBL28800761 | 0.78 | FDPS (0.58) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6191319 | 0.76 | FDPS (0.52) | FDPSNAPRTCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102333769-B | Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, preparation thereof, and therapeutic use as HIF activators | SANOFI AVENTIS | 2014-08-27 | — | — | CN | disclosed |
| CN-102333769-A | Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, preparation thereof, and therapeutic use as HIF activators | SANOFI AVENTIS | 2012-01-25 | — | — | CN | disclosed |