SCHEMBL27845488

SCHEMBL27845488

Brc1c2ccccc2c(-c2ccc(-c3cccnc3)c3ccccc23)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 6/20 0.50
CYP11B2 P19099 5/20 0.49
CYP3A4 P08684 4/20 0.45
CYP2A6 P11509 4/20 0.45
ALDH1A1 P00352 2/20 0.45
CYP1A2 P05177 1/20 0.45
NUDT1 P36639 1/20 0.43
GPR84 Q9NQS5 1/20 0.42
IDO1 P14902 1/20 0.41
LRRK2 Q5S007 1/20 0.41
TP53 P04637 2/20 0.41
NPC1 O15118 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
CKS1B P61024 2/20 0.41
SKP2 Q13309 2/20 0.41
GSK3B P49841 1/20 0.41
DYRK1A Q13627 1/20 0.41
CYP17A1 P05093 3/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10016740 0.86 CYP11B1 (0.53) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL2813022 0.86 CYP2A6 (0.52) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL13907276 0.84 CYP11B1 (0.66) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL17320748 0.83 CYP2A6 (0.50) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL18165295 0.83 CYP11B1 (0.49) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL22007100 0.81 CYP11B1 (0.51) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL22470317 0.81 CYP2A6 (0.52) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL10016791 0.81 CYP11B1 (0.54) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1
SCHEMBL27845495 0.81 IMPDH2 (0.43) ALDH1A1NPC1RAB9AGSK3BDYRK1A
SCHEMBL17539980 0.81 CYP11B1 (0.51) CYP11B1CYP11B2CYP3A4CYP2A6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102382042-A Anthracene derivant and organic electroluminescence element using same JNC KK 2012-03-21 CN disclosed