Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.54 |
| ▸ | MTOR | P42345 | 16/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072362 | 0.88 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1073196 | 0.84 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL993047 | 0.84 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL12830822 | 0.84 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL24270518 | 0.83 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL29492711 | 0.83 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL31439304 | 0.82 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15747766 | 0.82 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL22616561 | 0.78 | MTOR (0.73) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14872946 | 0.76 | MTOR (0.54) | PIK3CAMTORPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102399218-A | Triheterocyclic compounds and their use as PI3K inhibitors | HUTCHISON MEDIPHARMA LTD | 2012-04-04 | — | — | CN | disclosed |