Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.68 |
| ▸ | MTOR | P42345 | 18/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439304 | 1.00 | PIK3CA (0.68) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15615901 | 0.89 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL18174513 | 0.83 | PIK3CA (0.50) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL2281822 | 0.83 | MTOR (0.79) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1072362 | 0.82 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL31439311 | 0.82 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15747768 | 0.82 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL27846629 | 0.82 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL2281788 | 0.81 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL2285699 | 0.81 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014079364-A1 | IMIDAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 北京富龙康泰生物技术有限公司 (CN) | 2014-05-30 | — | — | WO | disclosed |