Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.87 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | CDK8 | P49336 | 2/20 | 0.59 |
| ▸ | RAF1 | P04049 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17179246 | 0.93 | KDR (1.00) | KDRRETCDK8RAF1NTRK1 | |
| SCHEMBL28793967 | 0.91 | KDR (0.72) | KDRRETCDK8NTRK1 | |
| SCHEMBL27847472 | 0.91 | KDR (0.72) | KDRRETCDK8RAF1NTRK1 | |
| SCHEMBL27864410 | 0.91 | KDR (0.72) | KDRRETRAF1NTRK1 | |
| SCHEMBL5338565 | 0.90 | KDR (0.71) | KDRRETRAF1 | |
| SCHEMBL27882962 | 0.90 | KDR (0.88) | KDRRETRAF1FLT1 | |
| SCHEMBL27864336 | 0.90 | KDR (0.71) | KDRRETCDK8NTRK1 | |
| SCHEMBL27847248 | 0.90 | KDR (0.71) | KDRRETRAF1NTRK1 | |
| SCHEMBL27846440 | 0.90 | KDR (0.70) | KDRRETCDK8RAF1NTRK1 | |
| SCHEMBL572529 | 0.89 | KDR (0.85) | KDRRETRAF1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102408408-A | Aryl urea derivative with anti-tumor effect | UNIV PEKING FOUNDER GROUP CO | 2012-04-11 | — | — | CN | claimed |
| CN-102408408-A | Aryl urea derivative with anti-tumor effect | UNIV PEKING FOUNDER GROUP CO | 2012-04-11 | — | — | CN | disclosed |