Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27847472 | 0.91 | KDR (0.72) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL27864410 | 0.91 | KDR (0.72) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL28793967 | 0.91 | KDR (0.72) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL27847248 | 0.90 | KDR (0.71) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL27847250 | 0.90 | KDR (0.87) | KDRNTRK1RETCDK8 | |
| SCHEMBL27847260 | 0.87 | KDR (0.67) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL573353 | 0.84 | KDR (0.74) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL27866671 | 0.83 | KDR (0.84) | KDRPDGFRBPDGFRAFLT3RET | |
| SCHEMBL5440735 | 0.83 | KDR (0.61) | KDRNTRK1CSF1RPDGFRBPDGFRA | |
| SCHEMBL17179246 | 0.83 | KDR (1.00) | KDRNTRK1CSF1RPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102408408-A | Aryl urea derivative with anti-tumor effect | UNIV PEKING FOUNDER GROUP CO | 2012-04-11 | — | — | CN | claimed |
| CN-102408408-A | Aryl urea derivative with anti-tumor effect | UNIV PEKING FOUNDER GROUP CO | 2012-04-11 | — | — | CN | disclosed |