Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27967466 | 0.82 | HDAC8 (0.33) | — | |
| SCHEMBL27895547 | 0.81 | — | — | |
| SCHEMBL27869269 | 0.81 | — | — | |
| SCHEMBL28281155 | 0.78 | HDAC8 (0.31) | — | |
| SCHEMBL27861814 | 0.78 | — | — | |
| SCHEMBL27610224 | 0.78 | PARP15 (0.30) | — | |
| SCHEMBL28098380 | 0.77 | — | — | |
| SCHEMBL27764247 | 0.76 | SLC6A3 (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12310544 | 0.75 | — | — | |
| SCHEMBL2094497 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102428075-B | crystalline tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-05-11 | — | — | CN | disclosed |
| CN-104968650-A | Modified release formulations of Oprozomib | ONYX THERAPEUTICS INC | 2015-10-07 | — | — | CN | disclosed |
| CN-102414208-B | Isoxazole-thiazole derivatives as GABAA a receptor inverse agonists for use in the treatment of cognitive disorders | HOFFMANN LA ROCHE | 2014-11-05 | — | — | CN | disclosed |
| CN-102428075-A | Crystalline tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS INC | 2012-04-25 | — | — | CN | disclosed |
| CN-102414208-A | Isoxazole-thiazole derivatives as inverse agonists of GABAA receptors for use in the treatment of cognitive disorders | HOFFMANN LA ROCHE | 2012-04-11 | — | — | CN | disclosed |