SCHEMBL2785178

SCHEMBL2785178

Nc1ccc2cc3cccc(N)c3cc2c1C(O)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
KDM4E B2RXH2 4/20 0.42
KMT2A Q03164 4/20 0.42
HPGD P15428 4/20 0.42
HSD17B10 Q99714 4/20 0.42
MEN1 O00255 3/20 0.42
MAPT P10636 3/20 0.42
POLB P06746 3/20 0.42
GLA P06280 2/20 0.42
GAA P10253 2/20 0.42
ATM Q13315 1/20 0.42
F2 P00734 1/20 0.41
PLG P00747 1/20 0.41
PLAU P00749 1/20 0.41
PLAT P00750 1/20 0.41
KLK1 P06870 1/20 0.41
PRSS1 P07477 1/20 0.41
CYP3A4 P08684 3/20 0.39
TSHR P16473 2/20 0.39
KEAP1 Q14145 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2782957 0.95 ALDH1A1 (0.43) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2786121 0.91 SMN1; SMN2 (0.43) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2783950 0.85 SMN1; SMN2 (0.42) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2784728 0.85 SMN1; SMN2 (0.42) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2783869 0.85 SMN1; SMN2 (0.42) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2784474 0.85 SMN1; SMN2 (0.44) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2783791 0.82 KDM4E (0.53) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2783796 0.82 KDM4E (0.45) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2783729 0.82 KDM4E (0.45) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL2784181 0.81 KDM4E (0.55) ALDH1A1KDM4EKMT2AHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130085237-A1 Fluorinated Diamine and Polymer Formed Therefrom CENTRAL GLASS COMPANY, LIMITED (JP) 2013-04-04 US disclosed
US-20100029895-A1 Fluorinated Diamine and Polymer Formed Therefrom CENTRAL GLASS COMPANY, LIMITED (JP) 2010-02-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029895-A1 Fluorinated Diamine and Polymer Formed Therefrom AFF2, AFF1, AFF4 ALDH1A1 931/4885KDM4E 1841/4885KMT2A 662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.