Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27868815 | 0.87 | SYK (0.40) | PIM1PIM3PIM2ROCK2ACVR1 | |
| SCHEMBL27868807 | 0.83 | PIM1 (0.38) | PIM1PIM3PIM2ROCK2ACVR1 | |
| SCHEMBL781536 | 0.83 | ROCK2 (0.40) | PIM1PIM3PIM2ROCK2ACVR1 | |
| Hydrochloric Acid SCHEMBL16162193 | 0.82 | FGFR1 (0.40) | PIM1PIM3PIM2ROCK2ALK | |
| SCHEMBL780100 | 0.74 | PIK3CA (0.46) | ROCK2ROCK1MAPTSMN1; SMN2 | |
| SCHEMBL16168342 | 0.74 | PIM1 (0.52) | PIM1PIM3PIM2ROCK2ACVR1 | |
| SCHEMBL780600 | 0.74 | ROCK2 (0.42) | PIM1PIM3PIM2ROCK2ROCK1 | |
| SCHEMBL20572016 | 0.74 | ROCK2 (0.42) | PIM1PIM3PIM2ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL781422 | 0.74 | PIK3CA (0.45) | ROCK2ROCK1FGFR1FGFR2FGFR3 | |
| SCHEMBL782016 | 0.74 | ROCK2 (0.42) | PIM1PIM3PIM2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459234-B | Substituted benzotriazines and quinoxalines as P70S6 kinase inhibitors | SENTINEL ONCOLOGY LTD. (GB) | 2014-10-15 | — | — | CN | claimed |
| CN-102459234-A | Substituted benzotriazines and quinoxalines as P70S6 kinase inhibitors | SENTINEL ONCOLOGY LTD | 2012-05-16 | — | — | CN | claimed |
| CN-102459234-B | Substituted benzotriazines and quinoxalines as P70S6 kinase inhibitors | SENTINEL ONCOLOGY LTD. (GB) | 2014-10-15 | — | — | CN | disclosed |
| CN-102459234-A | Substituted benzotriazines and quinoxalines as P70S6 kinase inhibitors | SENTINEL ONCOLOGY LTD | 2012-05-16 | — | — | CN | disclosed |