Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.56 |
| ▸ | JAK1 | P23458 | 7/20 | 0.56 |
| ▸ | TYK2 | P29597 | 7/20 | 0.56 |
| ▸ | JAK3 | P52333 | 7/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 6/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142282 | 0.87 | JAK2 (0.69) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL27833910 | 0.84 | PARP1 (0.52) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL27852007 | 0.81 | PARP1 (0.55) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL27997776 | 0.79 | JAK2 (0.46) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL141763 | 0.78 | JAK2 (0.72) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL27833940 | 0.75 | JAK2 (0.76) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL27998023 | 0.74 | JAK2 (0.53) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL139641 | 0.73 | JAK2 (0.60) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL140129 | 0.72 | JAK2 (1.00) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL140372 | 0.71 | JAK2 (0.61) | JAK2JAK1TYK2JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102325752-A | Carbazole and carboline kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2012-01-18 | — | — | CN | disclosed |