Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 13/20 | 0.51 |
| ▸ | BTK | Q06187 | 6/20 | 0.51 |
| ▸ | JAK1 | P23458 | 6/20 | 0.50 |
| ▸ | TYK2 | P29597 | 6/20 | 0.50 |
| ▸ | JAK3 | P52333 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL140372 | 0.85 | JAK2 (0.61) | JAK2BTKJAK1TYK2JAK3 | |
| SCHEMBL27833910 | 0.84 | PARP1 (0.52) | PARP1HPGDJAK2BTKJAK1 | |
| SCHEMBL27852002 | 0.81 | JAK2 (0.56) | PARP1HPGDJAK2BTKJAK1 | |
| SCHEMBL13616256 | 0.77 | HPGD (0.67) | HPGDGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10194842 | 0.77 | HPGD (0.71) | HPGDGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL139641 | 0.74 | JAK2 (0.60) | JAK2BTKJAK1TYK2JAK3 | |
| SCHEMBL26465353 | 0.74 | HPGD (0.59) | HPGDGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27998023 | 0.73 | JAK2 (0.53) | PARP1HPGDJAK2BTKJAK1 | |
| SCHEMBL27998029 | 0.73 | KMT2A (0.50) | HPGDJAK2JAK1TYK2JAK3 | |
| SCHEMBL12311738 | 0.73 | HPGD (0.77) | HPGDGAANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102325752-A | Carbazole and carboline kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2012-01-18 | — | — | CN | disclosed |