Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 8/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27853064 | 0.88 | PLG (0.44) | PLGCCR5EGLN1 | |
| SCHEMBL587177 | 0.87 | PLG (0.43) | PLGCCR5KMT2AEGLN1HRH3 | |
| SCHEMBL27852995 | 0.87 | PLG (0.56) | PLG | |
| SCHEMBL27852916 | 0.86 | PLG (0.55) | PLG | |
| SCHEMBL27965394 | 0.85 | PLG (0.45) | PLG | |
| SCHEMBL581666 | 0.84 | PLG (0.46) | PLG | |
| SCHEMBL27965499 | 0.83 | PLG (0.45) | PLG | |
| SCHEMBL581900 | 0.83 | PLG (0.41) | PLGCCR5KMT2AEGLN1HRH3 | |
| SCHEMBL586984 | 0.83 | PLG (0.41) | PLGCCR5KMT2AEGLN1HRH3 | |
| SCHEMBL587616 | 0.83 | PLG (0.41) | PLGCCR5KMT2AEGLN1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459246-B | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2014-05-07 | — | — | CN | disclosed |
| CN-102459246-A | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |