Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993718 | 0.78 | PTPN11 (0.30) | — | |
| SCHEMBL1948611 | 0.77 | HPGD (0.40) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL484974 | 0.75 | CYP2D6 (0.33) | EPHX2CYP2D6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23754166 | 0.74 | OPRM1 (0.33) | — | |
| SCHEMBL26926194 | 0.74 | OPRM1 (0.33) | — | |
| SCHEMBL18342373 | 0.71 | USP2 (0.34) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL16765222 | 0.71 | EPHX2 (0.33) | EPHX2CYP2D6SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL27196346 | 0.71 | EPHX2 (0.33) | EPHX2CYP2D6SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL25233382 | 0.71 | EPHX2 (0.33) | EPHX2CYP2D6SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL21979035 | 0.70 | EPHX2 (0.44) | EPHX2CYP2D6NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102510865-B | Nitrogen-containing spiro compound and pharmaceutical use thereof | JAPAN TOBACCO INC | 2015-04-15 | — | — | CN | disclosed |
| CN-102510865-A | Nitrogen-containing spiro compound and pharmaceutical use thereof | JAPAN TOBACCO INC | 2012-06-20 | — | — | CN | disclosed |