Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | GLA | P06280 | 2/20 | 0.71 |
| ▸ | ACHE | P22303 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL29114524 | 0.86 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL27450140 | 0.86 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDGLAACHE | |
| Phenazine SCHEMBL27991538 | 0.85 | MAPT (0.65) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL4972293 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL29352289 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL3045498 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL1772714 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL8339 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL28830169 | 0.82 | MAPT (0.83) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL28646458 | 0.82 | ALDH1A1 (0.83) | ALDH1A1MAPTHPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117897380-A | Pyridazinone or pyridone compounds, process for their preparation and their use | 益方生物科技(上海)股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-117298275-A | Method for treating hematological malignancies and ewing's sarcoma | 库拉肿瘤学公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-114867726-B | Small molecule inhibitors of KRAS G12C mutants | 默沙东有限责任公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-115968286-A | Heteroaryl compounds, their preparation and use | 益方生物科技(上海)股份有限公司 | 2023-04-14 | — | — | CN | disclosed |
| CN-112040979-A | Antibodies to signal-modulating protein alpha and methods of use | ALX肿瘤生物技术公司 | 2020-12-04 | — | — | CN | disclosed |
| CN-110526912-A | Heteroaryl compound for kinase inhibition | ARIAD PHARMA INC | 2019-12-03 | — | — | CN | disclosed |
| CN-110461872-A | CD47 antigen binding units and uses thereof | ZAI LAB SHANGHAI CO LTD | 2019-11-15 | — | — | CN | disclosed |
| CN-110382482-A | Condensed miscellaneous-Heterobicyclic compounds and its application method | 亚瑞克西斯制药公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110382483-A | Condensed N- heterocyclic compound and its application method | 亚瑞克西斯制药公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-110366550-A | Benzoisothiazole, isothiazolo [3,4-b ] pyridine, quinazoline, phthalazine, pyrido [2,3-d ] pyridazine and pyrido [2,3-d ] pyrimidine derivatives as KRAS G12C inhibitors for the treatment of lung, pancreatic or colorectal cancer | 美国安进公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105189456-B | Covalent inhibitors of KRAS G12C | 亚瑞克西斯制药公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-106559991-A | Heteroaryl compounds for kinase inhibition | 阿里亚德医药股份有限公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-106488910-A | Inhibitors of kras g12c | 亚瑞克西斯制药公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-103025758-B | IL-1 binding proteins | ABBVIE 公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-105492011-A | Therapeutic synergy of undesirable chemical compounds | BROWN DENNIS M | 2016-04-13 | — | — | CN | disclosed |
| CN-105228649-A | HCV antigen-antibody combination assays and methods and compositions for use therein | ABBOTT LAB | 2016-01-06 | — | — | CN | disclosed |
| CN-104203278-A | IL-1 binding proteins | ABBVIE INC | 2014-12-10 | — | — | CN | disclosed |
| CN-103476250-A | Compositions and methods for improving the therapeutic efficacy of suboptimally administered compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol | DEL MAR PHARMACEUTICALS | 2013-12-25 | — | — | CN | disclosed |
| CN-103002738-A | Chemical compounds, compositions and methods for kinase modulation | INTELLIKINE INC | 2013-03-27 | — | — | CN | disclosed |
| CN-102271513-A | Benzoxazole kinase inhibitors and methods of use | — | 2011-12-07 | — | — | CN | disclosed |