Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | EYA2 | O00167 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8735298 | 0.81 | TDP1 (0.31) | TDP1EYA2APPACEFFAR3 | |
| Ammonia Solution, Strong SCHEMBL27472350 | 0.79 | EYA2 (0.30) | TDP1EYA2APPACE | |
| SCHEMBL21626180 | 0.77 | — | — | |
| SCHEMBL1274837 | 0.74 | — | — | |
| SCHEMBL959395 | 0.72 | TDP1 (0.31) | TDP1EYA2APPACEBLM | |
| SCHEMBL11189750 | 0.72 | CYP1A2 (0.41) | TDP1MGAMGAASIMGAM2 | |
| SCHEMBL27519289 | 0.72 | FFAR3 (0.38) | TDP1EYA2APPACEFFAR3 | |
| SCHEMBL3338460 | 0.72 | FFAR3 (0.38) | TDP1EYA2APPACEFFAR3 | |
| SCHEMBL8663088 | 0.72 | FFAR3 (0.38) | TDP1EYA2APPACEFFAR3 | |
| SCHEMBL3326949 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103896796-A | Substituted Aminopropionic Derivatives as Neprilysin inhibitors | NOVARTIS INST FOR BIOMEDICAL RES INC | 2014-07-02 | — | — | CN | disclosed |
| CN-103313708-A | Method of treating contrast-induced nephropathy | NOVARTIS AG | 2013-09-18 | — | — | CN | disclosed |
| CN-102574801-A | Substituted aminopropionic acid derivatives as enkephalinase inhibitors | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |