EYA2

Protein phosphatase EYA2 · O00167 · EYA2 on Sugi Atlas →

5,052 patent compounds predicted against EYA2, 3,673 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Edetic Acid (SCHEMBL1373)	1.00	1/20
Edetic Acid (SCHEMBL15136)	1.00	1/20
Benzbromarone (SCHEMBL48993)	1.00	1/20
Edetic Acid (SCHEMBL905)	0.93	1/20
Pentetic Acid (SCHEMBL17138)	0.93	1/20
Edetic Acid (SCHEMBL33500)	0.93	1/20
Edetic Acid (SCHEMBL42055)	0.93	1/20
Edetic Acid (SCHEMBL42426)	0.93	1/20
Edetic Acid (SCHEMBL43566)	0.93	1/20
Edetic Acid (SCHEMBL59497)	0.93	1/20
Edetic Acid (SCHEMBL65334)	0.93	1/20
Edetic Acid (SCHEMBL119008)	0.93	1/20
Edetic Acid (SCHEMBL120660)	0.93	1/20
SCHEMBL137691	0.93	1/20
Edetic Acid (SCHEMBL144662)	0.93	1/20
Edetic Acid (SCHEMBL191925)	0.93	1/20
Edetic Acid (SCHEMBL193505)	0.93	1/20
Edetic Acid (SCHEMBL285310)	0.93	1/20
Edetic Acid (SCHEMBL394052)	0.93	1/20
Edetic Acid (SCHEMBL424997)	0.93	1/20

Clinical trials — most relevant to EYA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients	PHASE1/PHASE2	COMPLETED
Safety and Efficacy of Stem Cell Small Extracellular Vesicles in Patients With Retinitis Pigmentosa	PHASE1/PHASE2	RECRUITING
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma	PHASE2	UNKNOWN
Rate of Progression in EYS Related Retinal Degeneration	nan	ACTIVE_NOT_RECRUITING
Natural History Study of Patients With EYS-Associated RP	nan	RECRUITING
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions	nan	RECRUITING
National Cohort on Congenital Defects of the Eye	nan	RECRUITING
Evolution of Visual Impairment During Pseudoxanthoma Elasticum	nan	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children	nan	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation	nan	RECRUITING
iSITE: Investigation of Somatic Alterations in Tumours of the Eye	nan	COMPLETED
Proteomic Study of Tears From Patients With a PAX6 Mutation	nan	COMPLETED
NGS Panel of Incomplete Forms of Ocular Albinism	nan	COMPLETED
New Biopsy Technique for Uveal Melanoma	nan	COMPLETED
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing	nan	UNKNOWN
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Family Study of Melanoma in Italy	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma	nan	COMPLETED
Validation of a Molecular Prognostic Test for Eye Melanoma	nan	WITHDRAWN
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a EYA2 binder may also engage these)

Protein	Name	Similarity
P97767	—	1.000	P97767 →
O08575	—	1.000	O08575 →
Q58DB6	—	0.999	Q58DB6 →
O95677	—	0.998	O95677 →
Q9Z191	—	0.998	Q9Z191 →
EYA3	Protein phosphatase EYA3	0.995	landscape →
Q6E3D4	—	0.994	Q6E3D4 →
Q6PF39	—	0.994	Q6PF39 →
Q99502	—	0.994	Q99502 →
Q5RFT9	—	0.993	Q5RFT9 →
Q04461	—	0.992	Q04461 →
P22016	—	0.992	P22016 →
P97480	—	0.992	P97480 →
P43696	—	0.992	P43696 →
Q2UBW0	—	0.992	Q2UBW0 →
Q9FNY0	—	0.992	Q9FNY0 →
Q2UMR9	—	0.992	Q2UMR9 →
Q09801	—	0.992	Q09801 →
C1GR85	—	0.992	C1GR85 →
Q75F26	—	0.992	Q75F26 →
Q92539	—	0.991	Q92539 →
Q0CZG5	—	0.991	Q0CZG5 →
O04609	—	0.991	O04609 →
F5HB62	—	0.991	F5HB62 →
P97588	—	0.991	P97588 →
Q96MY1	—	0.991	Q96MY1 →
Q700C2	—	0.991	Q700C2 →
P53938	—	0.991	P53938 →
P20945	—	0.991	P20945 →
Q4WWN2	—	0.991	Q4WWN2 →