Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061612 | 0.81 | MEN1 (0.53) | KMT2AMEN1RXFP1POLBHTT | |
| SCHEMBL27530714 | 0.77 | POLB (0.54) | KMT2AMEN1POLBHTTLMNA | |
| SCHEMBL29450270 | 0.76 | POLB (0.70) | KMT2APOLBHTTLMNAMAPT | |
| SCHEMBL9694998 | 0.76 | POLB (0.70) | KMT2APOLBHTTLMNAMAPT | |
| SCHEMBL31060776 | 0.75 | POLB (0.49) | KMT2AMEN1POLBHTTLMNA | |
| SCHEMBL7468007 | 0.73 | KMT2A (0.60) | KMT2AMEN1RXFP1POLBHTT | |
| SCHEMBL30646027 | 0.70 | MEN1 (0.44) | KMT2AMEN1RXFP1HTTLMNA | |
| SCHEMBL29111047 | 0.70 | MEN1 (0.44) | KMT2AMEN1RXFP1HTTLMNA | |
| SCHEMBL1283381 | 0.70 | MEN1 (0.52) | KMT2AMEN1RXFP1HTTMAPT | |
| SCHEMBL4727429 | 0.69 | KMT2A (0.56) | KMT2AMEN1RXFP1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111440177-B | Substituted pyrazolo [1,5-a ] pyrimidine compound and preparation method and application thereof | 辽宁大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-111440177-A | Novel substituted pyrazolo [1,5-a ] pyrimidine compound and preparation method and application thereof | 辽宁大学 | 2020-07-24 | — | — | CN | disclosed |
| CN-102388024-A | Malate salt of N- (4- { [6, 7-bis (methyloxy) quinolin-4-yl ] oxy } phenyl) -N' - (4-fluorophenyl) cyclopropane-1, 1-dicarboxamide and crystalline form thereof for cancer treatment | EXELIXIS INC | 2012-03-21 | — | — | CN | disclosed |