Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784158 | 0.90 | CACNA1B (0.39) | PGRNR3C1NR3C2ARPIK3CD | |
| SCHEMBL2784455 | 0.88 | PGR (0.40) | PGRNR3C1NR3C2ARPIK3CD | |
| SCHEMBL2785852 | 0.86 | PGR (0.41) | PGRNR3C1NR3C2ARPIK3CD | |
| SCHEMBL2785099 | 0.81 | EPHX2 (0.42) | PGRPIK3CD | |
| SCHEMBL3014377 | 0.80 | PGR (0.58) | PGRNR3C1NR3C2ARPIK3CD | |
| SCHEMBL2787297 | 0.77 | PGR (0.49) | PGRPIK3CDTDP2 | |
| SCHEMBL1948699 | 0.77 | PGR (0.43) | PGRNR3C1NR3C2ARTDP2 | |
| SCHEMBL2785545 | 0.76 | PGR (0.46) | PGRPIK3CD | |
| SCHEMBL2785604 | 0.76 | PGR (0.50) | PGRPIK3CD | |
| SCHEMBL2784159 | 0.75 | PIK3CD (0.40) | PGRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |