Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 11/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785718 | 0.92 | PIM1 (0.39) | GRIN1GRIN2BCYP11B1CYP11B2 | |
| SCHEMBL2785099 | 0.90 | EPHX2 (0.42) | GRIN1GRIN2BPGREPHX2MAPK14 | |
| SCHEMBL2785994 | 0.87 | GRIN1 (0.38) | GRIN1GRIN2BBACE1BACE2 | |
| SCHEMBL2786610 | 0.86 | HDAC1 (0.38) | GRIN1GRIN2BPGRHDAC1HDAC8 | |
| SCHEMBL3020986 | 0.79 | PGR (0.55) | PGRHDAC1HDAC8HDAC6EPHX2 | |
| SCHEMBL3040774 | 0.75 | GRIN1 (0.40) | GRIN1GRIN2BBACE1BACE2PGR | |
| SCHEMBL2785774 | 0.75 | HDAC1 (0.37) | PGRHDAC1HDAC8HDAC6 | |
| SCHEMBL1951405 | 0.74 | PARP10 (0.43) | GRIN1GRIN2BBACE1PGRHDAC1 | |
| SCHEMBL2785545 | 0.74 | PGR (0.46) | GRIN1GRIN2BPGREPHX2 | |
| SCHEMBL2787297 | 0.73 | PGR (0.49) | GRIN1GRIN2BPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |