Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | SPR | P35270 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3296587 | 0.91 | HSD11B1 (0.62) | HSD11B1USP30SPRKDM4DPDE10A | |
| SCHEMBL1467761 | 0.89 | HSD11B1 (0.53) | HSD11B1USP30SPRMEN1ALDH1A1 | |
| SCHEMBL18711272 | 0.85 | HSD11B1 (0.50) | HSD11B1USP30SPRKDM4DDDB1 | |
| SCHEMBL13561970 | 0.82 | HSD11B1 (0.49) | HSD11B1USP30SPRMEN1ALDH1A1 | |
| SCHEMBL10196708 | 0.82 | HSD11B1 (0.49) | HSD11B1USP30SPRMEN1ALDH1A1 | |
| SCHEMBL10196718 | 0.82 | HSD11B1 (0.49) | HSD11B1USP30SPRMEN1ALDH1A1 | |
| SCHEMBL26666679 | 0.82 | HSD11B1 (0.54) | HSD11B1USP30SPRHPGDKDM4D | |
| SCHEMBL13738053 | 0.79 | HSD11B1 (0.62) | HSD11B1USP30SPRMEN1KMT2A | |
| SCHEMBL21285788 | 0.79 | HSD11B1 (0.69) | HSD11B1USP30SPRMEN1ALDH1A1 | |
| SCHEMBL5242729 | 0.79 | HSD11B1 (0.62) | HSD11B1USP30SPRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109897038-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-108175749-B | Melt-extruded solid dispersions containing apoptosis-inducing agents | 艾伯维爱尔兰无限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-102448959-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBOTT LAB | 2012-05-09 | — | — | CN | disclosed |