Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27883690 | 0.96 | BACE1 (0.49) | BACE1TTRKDM4EADORA3ADORA2A | |
| SCHEMBL29551111 | 0.76 | MAPT (0.60) | TTRKDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL497339 | 0.76 | MAPT (0.60) | TTRKDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL5024477 | 0.75 | PDE4A (0.50) | BACE1TTRKDM4EADORA3ADORA2A | |
| SCHEMBL3728321 | 0.74 | KDM4E (0.58) | BACE1KDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL24209663 | 0.74 | TTR (0.80) | TTRKDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL30610028 | 0.74 | TTR (0.80) | TTRKDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL27883688 | 0.74 | TTR (0.54) | TTRKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL26187355 | 0.74 | ELANE (0.69) | TTRKDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL1010933 | 0.74 | HTT (0.51) | BACE1TTRKDM4EADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102627522-A | Synthesis method of indenofluorene derivatives, isotruxene and mono-substituted isotruxene derivatives | UNIV EAST CHINA NORMAL | 2012-08-08 | — | — | CN | claimed |
| CN-102627522-A | Synthesis method of indenofluorene derivatives, isotruxene and mono-substituted isotruxene derivatives | UNIV EAST CHINA NORMAL | 2012-08-08 | — | — | CN | disclosed |